Hospitalist Articles 20 articles
RCT: In adults with STEMI-related cardiogenic shock, adding a microaxial flow pump to standard care reduced all-cause-mortality at 180 d.
N Engl J Med. 2024 Apr 18;390(15):1382-1393. doi: 10.1056/NEJMoa2312572. Epub 2024 Apr 7.
(Original study)
RCT: In acquired hemophilia A, prednisone plus daily cyclophosphamide vs. weekly rituximab did not differ for complete remission at 18 months.
Thromb Res. 2024 Mar 15;237:79-87. doi: 10.1016/j.thromres.2024.03.012.
(Original study)
Guideline: The International Society on Thrombosis and Haemostasis provided updated guidelines for antithrombotic therapy in patients with COVID-19 (hospitalized and nonhospitalized).
J Thromb Haemost. 2024 Mar 18:S1538-7836(24)00113-2. doi: 10.1016/j.jtha.2024.02.011.
(Evidence-based guideline)
RCT: In mild to moderate acute ischemic stroke in China, clopidogrel plus aspirin reduced early neurologic deterioration at 7 days vs. aspirin alone.
JAMA Neurol. 2024 Mar 11:e240146. doi: 10.1001/jamaneurol.2024.0146.
(Original study)
RCT: In complicated urinary tract infection, cefepime–taniborbactam vs meropenem reduced microbiological and clinical evidence of infection at 19 to 23 d in patients with qualifying gram-negative pathogens sensitive to both antibiotics.
N Engl J Med. 2024 Feb 15;390(7):611-622. doi: 10.1056/NEJMoa2304748.
(Original study)
RCT: In adults receiving IV therapy, midline catheters did not differ from peripherally inserted central catheters for catheter-related bloodstream infections.
JAMA Netw Open. 2024 Feb 5;7(2):e2355716. doi: 10.1001/jamanetworkopen.2023.55716.
(Original study)
Pooled RCTs: In acute ischemic stroke, the benefit of adding IV thrombolysis to thrombectomy was greatest when time from stroke symptom onset was short.
JAMA. 2024 Mar 5;331(9):764-777. doi: 10.1001/jama.2024.0589.
(Original study)
RCT: In low-risk S aureus bloodstream infection treated with IV antimicrobial therapy, effect of switching to oral therapy vs continuing IV therapy was assessed.
Lancet Infect Dis. 2024 Jan 17:S1473-3099(23)00756-9. doi: 10.1016/S1473-3099(23)00756-9.
(Original study)
RCT: In older patients hospitalized with serious illness, default palliative care consult orders vs usual care did not reduce length of hospital stay.
JAMA. 2024 Jan 16;331(3):224-232. doi: 10.1001/jama.2023.25092.
(Original study)
RCT: In adults with bacteremia due to Enterobacterales, structured de-escalation from antipseudomonal ß-lactams was noninferior to control for clinical cure at 3 to 5 d.
Lancet Infect Dis. 2024 Apr;24(4):375-385. doi: 10.1016/S1473-3099(23)00686-2. Epub 2024 Jan 9.
(Original study)
Placebo-controlled RCT: In mild ischemic stroke or high-risk TIA, adding clopidogrel to aspirin within 72 hrs reduced new stroke at 90 d and increased moderate-to-severe bleeding.
N Engl J Med. 2023 Dec 28;389(26):2413-2424. doi: 10.1056/NEJMoa2309137.
(Original study)
RCT: In acute intracerebral hemorrhage, adding early minimally invasive hematoma removal to medical management improved functional outcomes at 180 d.
N Engl J Med. 2024 Apr 11;390(14):1277-1289. doi: 10.1056/NEJMoa2308440.
(Original study)
Cohort study: In patients presenting to the ED with acute chest pain, the SVEAT score had 95% sensitivity and 84% specificity for predicting MACE at 30 d.
Am J Emerg Med. 2024 Mar 7;80:24-28. doi: 10.1016/j.ajem.2024.02.041.
(Original study)
Review: Effects of health care algorithms on racial and ethnic disparities in health and health care were assessed.
Ann Intern Med. 2024 Apr;177(4):484-496. doi: 10.7326/M23-2960. Epub 2024 Mar 12.
(Systematic review)
Review: In older persons, admission avoidance hospital at home services do not differ for mortality at 6 mo or hospital admission at 3 to 12 months.
Cochrane Database Syst Rev. 2024 Mar 5;3(3):CD007491. doi: 10.1002/14651858.CD007491.pub3.
(Systematic review)
RCT: In adults with acute MI, sacubitril-valsartan and ramipril did not differ for a composite of CV death or incident HF, regardless of type of MI.
J Am Coll Cardiol. 2024 Mar 5;83(9):904-914. doi: 10.1016/j.jacc.2024.01.002.
(Original study)
Review: Nutritional interventions to prevent and treat pressure ulcers were assessed.
Cochrane Database Syst Rev. 2024 Feb 12;2(2):CD003216. doi: 10.1002/14651858.CD003216.pub3.
(Systematic review)
RCT: In patients admitted to a rehabilitation hospital, an allied health assistant delivered falls education program did not differ from usual care for falls per bed days.
Age Ageing. 2024 Jan 2;53(1):afad250. doi: 10.1093/ageing/afad250.
(Original study)
RCT: In community-acquired pneumonia, adding oral clarithromycin to usual care increased early clinical response.
Lancet Respir Med. 2024 Apr;12(4):294-304. doi: 10.1016/S2213-2600(23)00412-5. Epub 2024 Jan 3.
(Original study)
Review: In hospitalized adults, the effect of neuromuscular electrical stimulation on hospital-acquired disability was assessed.
Age Ageing. 2023 Dec 1;52(12):afad236. doi: 10.1093/ageing/afad236.
(Systematic review)