http://journalwise.acponline.orgTop 5 Highest Rated Articles For Diabetes In The Last 30 Daysen-us6/20/2013 12:00:00 AMCopyright (C) HIRU - Mcmaster University 2013http://PLUS.mcmaster.ca RSS Generatorhttp://journalwise.acponline.org/RssArticle.aspx?DiabetesID=C2D5E4DBD6DFC6DBD8A6989E96A09DObesity (Silver Spring). 2013 Feb;21(2):238-47. doi: 10.1002/oby.20042.<br>OBJECTIVE: Therapies that lower blood glucose and provide weight loss may provide meaningful benefits for obese patients with type 2 diabetes mellitus (T2DM). This study assessed the efficacy of taspoglutide compared with placebo on glycemic control and weight in obese patients with T2DM inadequately controlled with metformin monotherapy. DESIGN AND METHODS: In a 24-week, randomized, double-blind, placebo-controlled, multicenter trial, obese adults with T2DM were randomized (1:1) to weekly subc...52179http://journalwise.acponline.org/RssArticle.aspx?DiabetesID=C2D5E4DBD6DFC6DBD8A6989E979F97BMJ. 2013 May 23;346:f2610. doi: 10.1136/bmj.f2610.<br>OBJECTIVE: To examine the risk of new onset diabetes among patients treated with different HMG-CoA reductase inhibitors (statins). DESIGN: Population based cohort study with time to event analyses to estimate the relation between use of particular statins and incident diabetes. Hazard ratios were calculated to determine the effect of dose and type of statin on the risk of incident diabetes. SETTING: Ontario, Canada. PARTICIPANTS: All patients aged 66 or older without diabetes who started treatm...52263http://journalwise.acponline.org/RssArticle.aspx?DiabetesID=C2D5E4DBD6DFC6DBD8A6989E959B9ADiabetes Obes Metab. 2013 Jun;15(6):564-71. doi: 10.1111/dom.12086. Epub 2013 Apr 1.<br>AIM: To evaluate health-related quality of life (health utility) scores in patients with diabetes receiving insulin degludec (IDeg) or insulin glargine (IGlar). METHODS: Patient-level data from six, randomized, controlled, open-label, multicentre, confirmatory, treat-to-target trials of 26- or 52 weeks` duration were pooled in this analysis. The Short Form 36 (SF-36) version-2 health questionnaire was completed by patients at baseline and end-of-trial. SF-36 scores for 4001 individual patients w...52026http://journalwise.acponline.org/RssArticle.aspx?DiabetesID=C2D5E4DBD6DFC6DBD8A6989E979D99Diabetes Care. 2013 May 22.<br>OBJECTIVETo compare efficacy and safety of lixisenatide once daily versus exenatide twice daily in type 2 diabetes inadequately controlled with metformin.RESEARCH DESIGN AND METHODSAdults with diabetes inadequately controlled (HbA1c 7-10%) with metformin were randomized to lixisenatide 20 mug once daily (n = 318) or exenatide 10 mug twice daily (n = 316) in a 24-week (main period), open-label, parallel-group, multicenter study. The primary objective was a noninferiority assessment of lixisenatid...52245http://journalwise.acponline.org/RssArticle.aspx?DiabetesID=C2D5E4DBD6DFC6DBD8A6989E9A9D98JAMA. 2013 Jun 5;309(21):2240-9. doi: 10.1001/jama.2013.5835.<br>IMPORTANCE: Controlling glycemia, blood pressure, and cholesterol is important for patients with diabetes. How best to achieve this goal is unknown. OBJECTIVE: To compare Roux-en-Y gastric bypass with lifestyle and intensive medical management to achieve control of comorbid risk factors. DESIGN, SETTING, AND PARTICIPANTS: A 12-month, 2-group unblinded randomized trial at 4 teaching hospitals in the United States and Taiwan involving 120 participants who had a hemoglobin A1c (HbA1c) level of 8.0...52544